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COMBIGAN brimonidine tartrate/timolol maleate ophthalmic Easily access Combigan programs and resources.ssued: January 22, 2008Invento s Chang; Chin-Ming Beck; Gary J. Pratt; Cynthia C. Batoosingh; Amy L. ssigne s Allergan, Inc. Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering how much does combigan eye drops cost composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.

Patent expiration dates: April 19, 2022Patent use: REDUCTION OF ELEVATED INTRAOCULAR PRESSURE IOP IN PATIENTS WITH GLAUCOMA OR OCULAR HYPERTENSION WHO REQUIRE ADJUNCTIVE OR REPLACEMENT THERAPY DUE TO INADEQUATELY CONTROLLED IOP. DOSE IS ONE DROP OF COMBIGAN IN THE AFFECTED EYE TWICE DAILY Combination of brimonidine and timolol for topical ophthalmic usePatent.

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The following adverse reactions were reported in 1% to 5% of patients: asthenia, blepharitis, corneal erosion, depression, epiphora, eye discharge, eye dryness, eye irritation, eye pain, eyelid edema, eyelid erythema, eyelid pruritus, foreign body sensation, headache, hypertension, oral dryness, somnolence, superficial punctate keratitis, and how much does combigan eye drops cost disturbance.An increased incidence of mammary adenocarcinomas in rodents has been associated with administration of several other therapeutic agents that elevate serum prolactin, but no correlation between serum prolactin levels and mammary tumors has been established in humans.

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